then centrifuged (14,000 x og, 10 min, 20 C) before transferring the into sample vials with glass inserts for analysis. Liquid chromatography mass spectrometry Analysis of plasma extracts was performed on an aijiren 6490 QQQ mass spectrometer with an aijiren series HPLC system and a ZORBAX eclipse plus C18 column (2.1x100mm 1.8μm,