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Remdesivir is a ProTide (Prodrug of nucleoTide). It is able to diffuse into cells where it is converted to GS-441524 mono-phosphate via the actions of esterases (CES1 and CTSA) and a phosphoamidase (); this in turn is further phosphorylated to its active metabolite triphosphate by nucleoside-phosphate kinases.
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